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Mouse Anti-UBE2J1 Recombinant Antibody (CBFYU-121) (CBMAB-U0121-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYU-121
Antibody Isotype
IgG2a, к
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein with GST tag. MW of the GST tag alone is 26 kD. Immunogen sequence: SPAVKRLMKE AAELKDPTDH YHAQPLEDNL FEWHFTVRGP PDSDFDGGVY HGRIVLPPEY PMKPPSIILL TANGRFEVGK KICLSISGHH PETWQPSWSI RTALLAIIGF.
Specificity
Human
Antibody Isotype
IgG2a, к
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 9-118

Target

Full Name
UBE2J1
Introduction
This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system. It catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD). Among its related pathways are Protein processing in endoplasmic reticulum and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Entrez Gene ID
51465
UniProt ID
Q9Y385
Alternative Names
NCUBE1; HSPC153; UBC6; Non-canonical ubiquitin-conjugating enzyme 1; Yeast ubiquitin-conjugating enzyme UBC6 homolog E; NCUBE-1; CGI-76; HSPC205; HSU93243; HSUBC6e; Ubc6p; ubiquitin-conjugating enzyme E2; J1; U; EC 6.3.2.19; HsUBC6e
Function
Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) and is essential for cells to recover from ER stress (PubMed:28321712).
Plays a role in MAPKAPK2-dependent translational control of TNF-alpha synthesis (PubMed:24020373).
Acts also as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the E3 ubiquitin-protein ligase RNF26 (PubMed:33472082).
(Microbial infection) Promotes Dengue virus RNA replication by negatively regulating IFN-beta signaling and mediating 'Lys-48'-linked ubiquitination on IRF3 (PubMed:30157886).
Biological Process
Biological Process negative regulation of retrograde protein transport, ER to cytosol Source:ParkinsonsUK-UCL1 Publication
Biological Process protein N-linked glycosylation via asparagine Source:UniProtKB1 Publication
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process regulation of macrophage cytokine production Source:Ensembl
Biological Process regulation of tumor necrosis factor production Source:Ensembl
Biological Process spermatid development Source:Ensembl
Biological Process ubiquitin-dependent ERAD pathway Source:UniProtKB1 Publication
Cellular Location
Endoplasmic reticulum membrane
Topology
Cytoplasmic: 1-282
Helical: 283-303
Lumenal: 304-318
PTM
Phosphorylated at Ser-184 in a cytosolic stress-dependent manner by MAP kinase p38 MAPKAPK2.
Phosphorylated UBE2J1 is rapidly ubiquitinated and subsequently degraded by the proteasome.
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For research use only. Not intended for any clinical use.

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