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Mouse Anti-UBE2D1 Recombinant Antibody (2C6) (CBMAB-A9704-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2C6
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
UBE2D1 (NP_003329, 1 a.a. ~ 94 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
UBE2D1
Introduction
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. [provided by RefSeq]
Entrez Gene ID
7321
UniProt ID
P51668
Alternative Names
E2(17)KB1; SFT; UBC4/5; UBCH5; UBCH5A
Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338).
In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386).
Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1 (PubMed:18042044, PubMed:18359941).
Ubiquitinates STUB1-associated HSP90AB1 in vitro (PubMed:18042044).
Lacks inherent specificity for any particular lysine residue of ubiquitin (PubMed:18042044).
Essential for viral activation of IRF3 (PubMed:19854139).
Mediates polyubiquitination of CYP3A4 (PubMed:19103148).
Biological Process
Biological Process negative regulation of BMP signaling pathway Source:Reactome
Biological Process negative regulation of transcription by RNA polymerase II Source:Reactome
Biological Process positive regulation of protein polyubiquitination Source:Ensembl
Biological Process positive regulation of protein ubiquitination Source:UniProtKB1 Publication
Biological Process protein K48-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein polyubiquitination Source:UniProtKB1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
PTM
Autoubiquitinated in vitro.
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For research use only. Not intended for any clinical use.

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