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Rabbit Anti-UBE2C Antibody (3BA1) (CBMAB-1732CQ)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
3BA1
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
Synthetic Peptide (GISAFPESDNLFK)
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ubiquitin Conjugating Enzyme E2 C
Introduction
This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and DNA Damage. GO annotations related to this gene include ligase activity and ubiquitin protein ligase binding.
Entrez Gene ID
11065
UniProt ID
O00762
Alternative Names
UBCH10; Ubiquitin Carrier Protein C; Ubiquitin-Protein Ligase C; EC 6.3.2.19; Cyclin-Selective Ubiquitin Carrier Protein; DJ447F3.2; Mitotic-Specific Ubiquitin-Conjugating Enzyme; Ubiquitin Carrier Protein E2-C; Ubiquitin-Conjugating Enzyme E2 C; UbcH10
Function
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.
Biological Process
Biological Process anaphase-promoting complex-dependent catabolic process Source:UniProtKB2 Publications
Biological Process cell division Source:UniProtKB-KW
Biological Process exit from mitosis Source:UniProtKB1 Publication
Biological Process free ubiquitin chain polymerization Source:UniProtKB1 Publication
Biological Process positive regulation of exit from mitosis Source:UniProtKB1 Publication
Biological Process positive regulation of ubiquitin protein ligase activity Source:UniProtKB1 Publication
Biological Process protein K11-linked ubiquitination Source:UniProtKB3 Publications
Biological Process protein K48-linked ubiquitination Source:UniProtKB1 Publication
Biological Process protein polyubiquitination Source:GO_Central1 Publication
Biological Process protein ubiquitination Source:UniProtKB1 Publication
Biological Process regulation of mitotic metaphase/anaphase transition Source:GO_Central1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:UniProtKB2 Publications
Cellular Location
anaphase-promoting complex
cytosol
nucleoplasm
nucleus
plasma membrane
ubiquitin ligase complex
PTM
Autoubiquitinated by the APC/C complex, leading to its degradation by the proteasome. Its degradation plays a central role in APC/C regulation, allowing cyclin-A accumulation before S phase entry. APC/C substrates inhibit the autoubiquitination of UBE2C/UBCH10 but not its E2 function, hence APC/C remaining active until its substrates have been destroyed.
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For research use only. Not intended for any clinical use.

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