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Mouse Anti-UBA7 Recombinant Antibody (CBYY-I0994) (CBMAB-I2162-YY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-I0994
Antibody Isotype
IgG1
Application
WB, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ubiquitin Like Modifier Activating Enzyme 7
Introduction
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferon-stimulated gene 15 protein.
Entrez Gene ID
7318
UniProt ID
P41226
Alternative Names
Ubiquitin Like Modifier Activating Enzyme 7; Ubiquitin-Activating Enzyme E1 Homolog; UBA7, Ubiquitin-Activating Enzyme E1; Ubiquitin-Activating Enzyme 7; UBE1L; UBE2; D8; UBA1, Ubiquitin-Activating Enzyme E1 Homolog B (Yeast);
Function
Activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Catalyzes the ISGylation of influenza A virus NS1 protein.
Biological Process
Biological Process cellular response to DNA damage stimulus Source:GO_Central1 Publication
Biological Process ISG15-protein conjugation Source:HGNC-UCL1 Publication
Biological Process modification-dependent protein catabolic process Source:Ensembl
Biological Process protein modification by small protein conjugation Source:GO_Central1 Publication
Biological Process protein modification process Source:HGNC-UCL1 Publication
Cellular Location
cytoplasm
cytosol
nucleoplasm
nucleus
PTM
ISGylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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