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Rabbit Anti-TYRP1 Recombinant Antibody (CBYJT-5567) (CBMAB-T5199-YJ)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
CBYJT-5567
Antibody Isotype
IgG, κ
Application
FC, ICC, IF, IHC-P, CyTOF

Basic Information

Immunogen
Recombinant human full-length TYRP1 protein
Specificity
Human, Mouse
Antibody Isotype
IgG, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Tyrosinase-Related Protein 1
Introduction
TYRP1 is a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. TYRP1 defects in TYRP1 are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. It catalyzes the oxidation of 5, 6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5, 6-quinone-2-carboxylic acid in the presence of bound Cu2+ ions (PubMed:28661582). TYRP1 may regulate or influence the type of melanin synthesized (PubMed:22556244, PubMed:16704458).
Entrez Gene ID
Human7306
Mouse22178
UniProt ID
HumanP17643
MouseP07147
Alternative Names
TRP; CAS2; CATB; GP75; OCA3; TRP1; TYRP; b-PROTEIN
Function
Plays a role in melanin biosynthesis (PubMed:22556244, PubMed:16704458, PubMed:23504663).
Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu2+ ions, but not in the presence of Zn2+ (PubMed:28661582).
May regulate or influence the type of melanin synthesized (PubMed:22556244, PubMed:16704458).
Also to a lower extent, capable of hydroxylating tyrosine and producing melanin (By similarity).
Biological Process
Biological Process acetoacetic acid metabolic process Source:Ensembl
Biological Process melanin biosynthetic process Source:Reactome
Biological Process melanocyte differentiation Source:GO_Central1 Publication
Biological Process melanosome organization Source:GO_Central1 Publication
Biological Process positive regulation of melanin biosynthetic process Source:CACAO1 Publication
Cellular Location
Melanosome membrane
Located to mature stage III and IV melanosomes and apposed endosomal tubular membranes. Transported to pigmented melanosomes by the BLOC-1 complex. Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38.
Involvement in disease
Albinism, oculocutaneous, 3 (OCA3):
An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Tyrosinase activity is normal and patients have only moderate reduction of pigment. The eyes present red reflex on transillumination of the iris, dilution of color of iris, nystagmus and strabismus. Darker-skinned individuals have bright copper-red coloration of the skin and hair.
Topology
Lumenal: 25-477
Helical: 478-501
Cytoplasmic: 502-537
PTM
Glycosylated.
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For research use only. Not intended for any clinical use.

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