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Mouse Anti-TUFM Recombinant Antibody (CBYJT-5371) (CBMAB-T4972-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-5371
Antibody Isotype
IgG1, κ
Application
ELISA

Basic Information

Immunogen
Full length recombinant corresponding to aa40-455 from human TUFM (AAH01633) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 40-455

Target

Full Name
TUFM Gene(Protein Coding) Tu Translation Elongation Factor, Mitochondrial
Introduction
TUFM is a protein which participates in protein translation in mitochondria. Mutations in TUFM have been associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy.
Entrez Gene ID
7284
UniProt ID
P49411
Alternative Names
Tu Translation Elongation Factor, Mitochondrial; EF-Tu; P43; Elongation Factor Tu, Mitochondrial; EF-TuMT; COXPD4; EFTU
Function
Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Also plays a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG-I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy.
Biological Process
Biological Process mitochondrial translational elongation Source:GO_Central1 Publication
Biological Process response to ethanol Source:Ensembl
Biological Process translational elongation Source:UniProtKB1 Publication
Cellular Location
Mitochondrion
Involvement in disease
Mitochondrion:
A mitochondrial disease resulting in neonatal lactic acidosis, rapidly progressive encephalopathy, severely decreased mitochondrial protein synthesis, and combined deficiency of mtDNA-related mitochondrial respiratory chain complexes.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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