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Mouse Anti-TSPAN7 Monoclonal Antibody (CL0262) (CBMAB-1667-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CL0262
Antibody Isotype
IgG1
Application
IHC, IHC-P, WB

Basic Information

Immunogen
A recombinant protein corresponding to amino acids: TFLRTYTDAMQTYNGNDERSRAVDHVQRSLSCCGVQNYTNWSTSPYFLEHGIPPSCCMNETDCNPQDLHNLTVAATKVNQKGCYDLVTSFMET
Specificity
Human, Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
Located in the sequence (NDERSRAVDHVQRSL)

Target

Full Name
TSPAN7 Gene(Protein Coding)


Tetraspanin 7
Introduction
TSPAN7 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and may have a role in the control of neurite outgrowth. It is known to complex with integrins. This gene is associated with X-linked cognitive disability and neuropsychiatric diseases such as Huntington's chorea, fragile X syndrome and myotonic dystrophy.
Entrez Gene ID
Human7102
Mouse21912
UniProt ID
HumanP41732
MouseQ62283
Alternative Names
A15; MXS1; CD231; MRX58; CCG-B7; TM4SF2; TALLA-1; TM4SF2b; DXS1692E
Function
May be involved in cell proliferation and cell motility.
Cellular Location
Membrane
Involvement in disease
Intellectual developmental disorder, X-linked 58 (XLID58):
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked intellectual disability, while syndromic intellectual disability presents with associated physical, neurological and/or psychiatric manifestations.
Topology
Cytoplasmic: 1-16
Helical: 17-40
Extracellular: 41-56
Helical: 57-75
Cytoplasmic: 76-86
Helical: 87-112
Extracellular: 113-213
Helical: 214-234
Cytoplasmic: 235-249
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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