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Rabbit Anti-TSHB Antibody (12BA6) (CBMAB-1704CQ)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
12BA6
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Synthetic Peptide (YALSQDVCTYR)
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 65-75

Target

Full Name
TSHB
Introduction
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Diseases associated with TSHB include Hypothyroidism, Congenital, Nongoitrous 4 and Central Congenital Hypothyroidism. Among its related pathways are Insulin secretion and G alpha (s) signalling events.
Entrez Gene ID
7252
UniProt ID
P01222
Alternative Names
Thyroid Stimulating Hormone; Beta; Thyroid-Stimulating Hormone Subunit Beta; Thyrotropin Beta Chain; TSH-B; Thyrotropin Beta Subunit; TSH-BETA; Thyrotropin Subunit Beta; Thyrotropin Alfa; CHNG4
Function
Indispensable for the control of thyroid structure and metabolism.
Biological Process
Biological Process anatomical structure morphogenesis Source:ProtInc1 Publication
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process G protein-coupled receptor signaling pathway Source:GO_Central1 Publication
Biological Process hormone-mediated signaling pathway Source:ComplexPortal
Biological Process response to calcium ion Source:Ensembl
Biological Process response to estrogen Source:Ensembl
Biological Process response to vitamin A Source:Ensembl
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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