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Mouse Anti-TSHB Recombinant Antibody (057-11003) (CBMAB-T4576-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
057-11003
Antibody Isotype
IgG1, κ
Application
EIA, ELISA, Immunoassay

Basic Information

Immunogen
Thyroid Stimulating Hormone (TSH)Specific to intact TSH. Reacts with TSH through the alpha subunit/hinge region. Does not react with free beta subunit. Has limited reactivity to free alpha subunit.Cross-reactivity:TSH - 100%hCG - 0.0%L
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TSHB
Introduction
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. TSHB is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis.
Entrez Gene ID
7252
UniProt ID
P01222
Alternative Names
Thyroid Stimulating Hormone Beta; Thyrotropin Beta Chain; TSH-BETA; TSH-B; Thyroid-Stimulating Hormone Subunit Beta; Thyrotropin Subunit Beta; Thyrotropin Alfa
Function
Indispensable for the control of thyroid structure and metabolism.
Biological Process
Biological Process anatomical structure morphogenesis Source:ProtInc1 Publication
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process G protein-coupled receptor signaling pathway Source:GO_Central1 Publication
Biological Process hormone-mediated signaling pathway Source:ComplexPortal
Biological Process response to calcium ion Source:Ensembl
Biological Process response to estrogen Source:Ensembl
Biological Process response to vitamin A Source:Ensembl
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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