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Mouse Anti-TRMT1 Recombinant Antibody (CBYJT-4867) (CBMAB-T4413-YJ)


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Summary

Host Animal
Mouse
Specificity
Human, Rat, Mouse
Clone
CBYJT-4867
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Specific for an epitope mapping between amino acids 221-246 within an internal region of TRMT1 of human origin
Specificity
Human, Rat, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 221-246

Target

Full Name
TRNA Methyltransferase 1
Introduction
TRMT1 is a tRNA-modifying enzyme that acts as a dimethyltransferase, modifying a single guanine residue at position 26 of the tRNA. The encoded enzyme has both mono- and dimethylase activity when exogenously expressed, and uses S-adenosyl methionine as a methyl donor. The C-terminal region of the encoded protein has both a zinc finger motif, and an arginine/proline-rich region. Mutations in TRMT1 have been implicated in autosomal recessive intellectual disorder (ARID).
Entrez Gene ID
Human55621
Mouse212528
Rat288914
UniProt ID
HumanQ9NXH9
MouseQ3TX08
RatQ496Z9
Alternative Names
TRNA Methyltransferase 1; TRNA 2, 2-Dimethylguanosine-26 Methyltransferase; TRNA(Guanine-26, N(2)-N(2)) Methyltransferase; TRNA(M(2, 2)G26)Dimethyltransferase; N(2), N(2)-Dimethylguanosine TRNA Methyltransferase; TRNA Methyltransferase 1 Homolog (S. Cerevisiae); TRNA (Guanine(26)-N(2))-Dimethyltransferase
Function
Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.
Biological Process
Biological Process tRNA modification Source:Reactome
Biological Process tRNA N2-guanine methylation Source:GO_Central1 Publication
Cellular Location
nucleoplasm
nucleus
Involvement in disease
Intellectual developmental disorder, autosomal recessive 68 (MRT68):
A form of intellectual disability, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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