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Rabbit Anti-TRH Recombinant Antibody (BA0069) (CBMAB-0885CQ)


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Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
BA0069
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Synthetic peptide aa 50-150 (Cysteine residue)
Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TRH Gene(Protein Coding) Thyrotropin Releasing Hormone
Introduction
This gene encodes a member of the thyrotropin-releasing hormone family.Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes.
Entrez Gene ID
Human7200
Mouse22044
Rat25569
UniProt ID
HumanP20396
MouseQ62361
RatP01150
Alternative Names
TRF; Pro-TRH
Function
As a component of the hypothalamic-pituitary-thyroid axis, it controls the secretion of thyroid-stimulating hormone (TSH) and is involved in thyroid hormone synthesis regulation. It also operates as modulator of hair growth. It promotes hair-shaft elongation, prolongs the hair cycle growth phase (anagen) and antagonizes its termination (catagen) by TGFB2. It stimulates proliferation and inhibits apoptosis of hair matrix keratinocytes.
Biological Process
Biological Process adult walking behavior Source:Ensembl
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process eating behavior Source:GO_Central1 Publication
Biological Process histamine metabolic process Source:GO_Central1 Publication
Biological Process hormone-mediated signaling pathway Source:InterPro
Biological Process negative regulation of glutamate secretion Source:GO_Central1 Publication
Biological Process positive regulation of gamma-aminobutyric acid secretion Source:GO_Central1 Publication
Biological Process positive regulation of insulin secretion Source:GO_Central1 Publication
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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