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Human Anti-TREM1 Recombinant Antibody (CBXC-0748) (CBMAB-C1862-CQ)


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Summary

Host Animal
Human
Specificity
Human
Clone
CBXC-0748
Antibody Isotype
IgG1
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Buffer containing stabilizer
Preservative
0.05% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TREM1 Gene(Protein Coding) Triggering Receptor Expressed On Myeloid Cells 1
Introduction
This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Entrez Gene ID
54210
UniProt ID
Q9NP99
Alternative Names
Triggering Receptor Expressed On Myeloid Cells 1; Triggering Receptor Expressed On Monocytes 1; TREM-1; CD354 Antigen; CD354;
Function
Isoform 1
Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses (PubMed:10799849, PubMed:21393102).
Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12 (PubMed:25595774, PubMed:17568691, PubMed:29568119).
In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma (PubMed:21659545, PubMed:14656437).
This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections (PubMed:17568691, PubMed:17098818).
By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis (PubMed:21393102, PubMed:11323674).
Isoform 2
Acts as a decoy receptor, counterbalancing TREM1 pro-inflammatory activity through the neutralization of its lignad.
Biological Process
Biological Process acute inflammatory response Source:InterPro
Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process humoral immune response Source:ProtInc1 Publication
Biological Process innate immune response Source:UniProtKB-KW
Biological Process intracellular signal transduction Source:ProtInc1 Publication
Biological Process neutrophil chemotaxis Source:GO_Central1 Publication
Biological Process neutrophil-mediated killing of gram-negative bacterium Source:GO_Central1 Publication
Cellular Location
Isoform 1
Cell membrane
Recruited to lipid rafts when activated.
Isoform 2
Secreted
Topology
Extracellular: 21-205
Helical: 206-226
Cytoplasmic: 227-234
PTM
Glycosylated.
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For research use only. Not intended for any clinical use.

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