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Rabbit Anti-TRAP1 Recombinant Antibody (D3D7N) (CBMAB-CP1076-LY)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
D3D7N
Antibody Isotype
IgG
Application
WB, IP, IF (ICC)

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro70 of human TRAP1/HSP75 protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TRAP1
Introduction
This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Entrez Gene ID
10131
UniProt ID
Q12931
Alternative Names
TNF Receptor Associated Protein 1; Tumor Necrosis Factor Type 1 Receptor-Associated Protein; TNFR-Associated Protein 1; TRAP-1; HSP 75; HSP75;
Function
Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.
Biological Process
Biological Process chaperone-mediated protein folding Source:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of cellular respiration Source:UniProtKB1 Publication
Biological Process negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide Source:ParkinsonsUK-UCLBy Similarity
Biological Process negative regulation of reactive oxygen species biosynthetic process Source:ParkinsonsUK-UCL1 Publication
Biological Process protein folding Source:GO_Central1 Publication
Biological Process translational attenuation Source:CACAO1 Publication
Cellular Location
Mitochondrion
Mitochondrion inner membrane
Mitochondrion matrix
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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