Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-TRAP1 Recombinant Antibody (3H4-2H6) (CBMAB-T4067-YJ)


See all TRAP1 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
3H4-2H6
Antibody Isotype
IgG1, κ
Application
WB, ICC, IF

Basic Information

Immunogen
Purified recombinant TRAP1
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TRAP1
Introduction
TRAP1 is a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. TRAP1 has ATPase activity and interacts with tumor necrosis factor type I. TRAP1 may function in regulating cellular stress responses.
Entrez Gene ID
Human10131
Mouse68015
Rat287069
UniProt ID
HumanQ12931
MouseQ9CQN1
RatQ5XHZ0
Alternative Names
TNF Receptor Associated Protein 1; Tumor Necrosis Factor Type 1 Receptor-Associated Protein; TNFR-Associated Protein 1; TRAP-1; HSP 75; HSP75
Function
Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.
Biological Process
Biological Process chaperone-mediated protein folding Source:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of cellular respiration Source:UniProtKB1 Publication
Biological Process negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide Source:ParkinsonsUK-UCLBy Similarity
Biological Process negative regulation of reactive oxygen species biosynthetic process Source:ParkinsonsUK-UCL1 Publication
Biological Process protein folding Source:GO_Central1 Publication
Biological Process translational attenuation Source:CACAO1 Publication
Cellular Location
Mitochondrion
Mitochondrion inner membrane
Mitochondrion matrix
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-TRAP1 Recombinant Antibody (3H4-2H6)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quoteOnline Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry