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Mouse Anti-Traf1 Recombinant Antibody (CBYJT-4491) (CBMAB-T3994-YJ)


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Summary

Host Animal
Mouse
Specificity
Mouse
Clone
CBYJT-4491
Antibody Isotype
IgG1, κ
Application
WB

Basic Information

Immunogen
TRAF1 antibody was raised against recombinant Mouse full length TRAF1 (1-410 a. a.).
Specificity
Mouse
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2, 50% Glycerol
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-410

Target

Full Name
TRAF1 Gene(Protein Coding) TNF Receptor Associated Factor 1
Introduction
Traf1 is an adapter molecule that regulates the activation of NF-kappa-B and JNK. It functions in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of an E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2 (By similarity).
Entrez Gene ID
22029
UniProt ID
P39428
Alternative Names
4732496E14Rik
Function
Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2.
Biological Process
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process positive regulation of JNK cascade Source:GO_Central1 Publication
Biological Process positive regulation of NF-kappaB transcription factor activity Source:UniProtKB1 Publication
Biological Process protein K63-linked ubiquitination Source:GO_Central1 Publication
Biological Process protein-containing complex assembly Source:ProtInc1 Publication
Biological Process regulation of extrinsic apoptotic signaling pathway Source:UniProtKB1 Publication
Biological Process regulation of I-kappaB kinase/NF-kappaB signaling Source:GO_Central1 Publication
Biological Process tumor necrosis factor-mediated signaling pathway Source:GO_Central1 Publication
Cellular Location
cytoplasm
cytoplasmic side of plasma membrane
cytosol
PTM
Polyubiquitinated by BIRC2 and/or BIRC3, leading to its subsequent proteasomal degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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