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Mouse Anti-TPM4 Antibody (LC24) (CBMAB-1701CQ)


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Summary

Host Animal
Mouse
Specificity
Human, Hamster
Clone
LC24
Antibody Isotype
IgG1
Application
FC, IF, IHC, WB

Basic Information

Immunogen
Recombinant human tropomyosin isoform 5 and 4 fusion (hTM5/4) protein (N-terminal half of hTM5 and C-terminal half of hTM4)
Specificity
Human, Hamster
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
C-terminal half of hTm4 (TPM4 Exon 9d)

Target

Full Name
Tropomyosin 4
Introduction
This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. Diseases associated with TPM4 include Inflammatory Myofibroblastic Tumor and Autosomal Dominant Macrothrombocytopenia. Among its related pathways are Striated Muscle Contraction and Dilated cardiomyopathy (DCM).
Entrez Gene ID
Human7170
Hamster100761146
UniProt ID
HumanP06753
HamsterA0A8C2QIX5
Alternative Names
HEL-S-108
Function
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments (By similarity).
Binds calcium (PubMed:1836432).
Biological Process
Biological Process actin filament organization Source:GO_Central1 Publication
Biological Process muscle contraction Source:GO_Central1 Publication
Biological Process osteoblast differentiation Source:UniProtKB1 Publication
Cellular Location
Cytoplasm, cytoskeleton
Associates with F-actin stress fibers.
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For research use only. Not intended for any clinical use.

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