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Mouse Anti-TP53I3 Recombinant Antibody (CBYJT-4271) (CBMAB-T3746-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4271
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Recombinant protein corresponding to aa1-332 from human TP53I3 expressed in E. coli
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Preservative
0.09% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-332

Target

Full Name
TP53I3 Gene(Protein Coding) Tumor Protein P53 Inducible Protein 3
Introduction
TP53I3 is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer.
Entrez Gene ID
9540
UniProt ID
Q53FA7
Alternative Names
Tumor Protein P53 Inducible Protein 3; P53-Induced Gene 3 Protein; PIG3; Tumor Protein P53-Inducible Protein 3; Quinone Oxidoreductase Homolog; Quinone Oxidoreductase PIG3
Function
Catalyzes the NADPH-dependent reduction of quinones (PubMed:19349281).
Exhibits a low enzymatic activity with beta-naphthoquinones, with a strong preference for the ortho-quinone isomer (1,2-beta-naphthoquinone) over the para isomer (1,4-beta-naphthoquinone). Also displays a low reductase activity for non-quinone compounds such as diamine and 2,6-dichloroindophenol (in vitro) (PubMed:19349281).
Involved in the generation of reactive oxygen species (ROS) (PubMed:19349281).
Biological Process
Biological Process NADP metabolic process Source:UniProtKB1 Publication
Cellular Location
Cytosol
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For research use only. Not intended for any clinical use.

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