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Mouse Anti-TNS3 Antibody (1E10) (CBMAB-1664CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1E10
Antibody Isotype
IgG
Application
ELISA, MA

Basic Information

Immunogen
Recombinant protein (aa 1162-1316; SH2 domain)
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TNS3
Introduction
TNS3 (Tensin 3) plays a role in actin remodeling. It involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. Diseases associated with TNS3 include Anisakiasis and Primary Syphilis. Among its related pathways are MET promotes cell motility and Signaling by GPCR.
Entrez Gene ID
64759
UniProt ID
Q68CZ2
Alternative Names
TEM6; TENS1
Function
May play a role in actin remodeling. Involved in the dissociation of the integrin-tensin-actin complex. EGF activates TNS4 and down-regulates TNS3 which results in capping the tail of ITGB1. Seems to be involved in mammary cell migration. May be involved in cell migration and bone development (By similarity).
Biological Process
Biological Process dephosphorylation Source:InterPro
Cellular Location
Cell junction, focal adhesion
PTM
EGF/epidermal growth factor induces tyrosine phosphorylation in a time- and dose-dependent manner.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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