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Mouse Anti-TNS1 Antibody (1G8) (CBMAB-1657CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1G8
Antibody Isotype
IgG
Application
ELISA, MA

Basic Information

Immunogen
Recombinant protein (aa 1449-1612; SH2 domain)
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TNS1
Introduction
The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. Also, this protein is a substrate of calpain II.
Entrez Gene ID
7145
UniProt ID
Q9HBL0
Alternative Names
TNS; MXRA6; MST091; MST122; MST127; MSTP091; MSTP122; MSTP127; PPP1R155
Function
Involved in fibrillar adhesion formation. May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton.
Biological Process
Biological Process fibroblast migration Source:GO_Central1 Publication
Cellular Location
Cell surface
Cell junction, focal adhesion
Cytoplasm, cytoskeleton
Localized at cell periphery preferentially to fibrillar adhesions than focal adhesions. Translocates from the cell edge to cell center in an ITGB1BP1-dependent manner.
PTM
Rapidly cleaved by calpain II.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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