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Mouse Anti-TNFSF18 Recombinant Antibody (CBYJT-3981) (CBMAB-T3393-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3981
Antibody Isotype
IgG1
Application
FC, Neut

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TNFSF18 Gene(Protein Coding) TNF Superfamily Member 18
Introduction
TNFSF18 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. TNFSF18 is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.
Entrez Gene ID
8995
UniProt ID
Q9UNG2
Alternative Names
TNF Superfamily Member 18; Tumor Necrosis Factor (Ligand) Superfamily, Member 18; Glucocorticoid-Induced TNF-Related Ligand; Activation-Inducible TNF-Related Ligand; HGITRL; AITRL; GITRL; TL6
Function
Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569).
Promotes leukocyte adhesion to endothelial cells (PubMed:23892569).
Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).
Biological Process
Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process negative regulation of apoptotic process Source:ProtInc1 Publication
Biological Process negative regulation of T-helper 17 cell lineage commitment Source:Ensembl
Biological Process positive regulation of cell adhesion Source:UniProtKB1 Publication
Biological Process positive regulation of inflammatory response Source:Ensembl
Biological Process positive regulation of leukocyte migration Source:UniProtKB1 Publication
Biological Process positive regulation of macrophage chemotaxis Source:Ensembl
Biological Process positive regulation of monocyte chemotaxis Source:Ensembl
Biological Process positive regulation of NF-kappaB transcription factor activity Source:UniProtKB
Biological Process positive regulation of tyrosine phosphorylation of STAT protein Source:UniProtKB1 Publication
Biological Process regulation of dendritic cell chemotaxis Source:Ensembl
Biological Process regulation of protein-containing complex assembly Source:Ensembl
Biological Process regulation of T cell proliferation Source:UniProtKB
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process T cell proliferation involved in immune response Source:UniProtKB
Biological Process tumor necrosis factor-mediated signaling pathway Source:UniProtKB
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-27
Helical: 28-48
Extracellular: 49-177
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For research use only. Not intended for any clinical use.

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