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Rat Anti-Tnfsf18 Recombinant Antibody (CBYJT-3986) (CBMAB-T3398-YJ)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYJT-3986
Antibody Isotype
IgG2a, κ
Application
ELISA, FC

Basic Information

Immunogen
Recombinant mouse GITRL
Specificity
Mouse
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TNFSF18 Gene(Protein Coding) TNF Superfamily Member 18
Introduction
Tnfsf18 is a cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can play a role as costimulator and lower the threshold for T-cell activation and T-cell proliferation. It is important for interactions between activated T-lymphocytes and endothelial cells. Tnfsf18 mediates activation of NF-kappa-B. It triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. Tnfsf18 promotes leukocyte adhesion to endothelial cells. Tnfsf18 regulates migration of monocytes from the splenic reservoir to sites of inflammation.
Entrez Gene ID
240873
UniProt ID
Q7TS55
Alternative Names
Gitrl; Tnlg2a
Function
Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569).
Promotes leukocyte adhesion to endothelial cells (PubMed:23892569).
Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).
Biological Process
Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process cell-cell signaling Source:ProtInc1 Publication
Biological Process negative regulation of apoptotic process Source:ProtInc1 Publication
Biological Process negative regulation of T-helper 17 cell lineage commitment Source:Ensembl
Biological Process positive regulation of cell adhesion Source:UniProtKB1 Publication
Biological Process positive regulation of inflammatory response Source:Ensembl
Biological Process positive regulation of leukocyte migration Source:UniProtKB1 Publication
Biological Process positive regulation of macrophage chemotaxis Source:Ensembl
Biological Process positive regulation of monocyte chemotaxis Source:Ensembl
Biological Process positive regulation of NF-kappaB transcription factor activity Source:UniProtKB
Biological Process positive regulation of tyrosine phosphorylation of STAT protein Source:UniProtKB1 Publication
Biological Process regulation of dendritic cell chemotaxis Source:Ensembl
Biological Process regulation of protein-containing complex assembly Source:Ensembl
Biological Process regulation of T cell proliferation Source:UniProtKB
Biological Process signal transduction Source:ProtInc1 Publication
Biological Process T cell proliferation involved in immune response Source:UniProtKB
Biological Process tumor necrosis factor-mediated signaling pathway Source:UniProtKB
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-27
Helical: 28-48
Extracellular: 49-177
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For research use only. Not intended for any clinical use.

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