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Mouse Anti-TNFRSF6B Recombinant Antibody (14L351) (CBMAB-D2335-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
14L351
Antibody Isotype
IgG1
Application
Neut, WB

Basic Information

Immunogen
Recombinant protein corresponding to human TNFRSF6B
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TNFRSF6B Gene(Protein Coding) TNF Receptor Superfamily Member 6b
Introduction
TNFRSF6B belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript.
Entrez Gene ID
8771
UniProt ID
O95407
Alternative Names
TNF Receptor Superfamily Member 6b; Tumor Necrosis Factor Receptor Superfamily, Member 6b, Decoy; Decoy Receptor For Fas Ligand; DCR3; M68; TR6; Tumor Necrosis Factor Receptor Superfamily Member 6B;
Function
Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.
Biological Process
Biological Process apoptotic process Source:UniProtKB-KW
Biological Process negative regulation of apoptotic process Source:ProtInc1 Publication
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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