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Rat Anti-Tnfrsf13c Recombinant Antibody (CBYJT-3736) (CBMAB-T3116-YJ)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYJT-3736
Antibody Isotype
IgG2b
Application
FC, FuncS

Basic Information

Immunogen
Y3 cells transfected with mouse BAFF-R
Specificity
Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TNFRSF13C Gene(Protein Coding) TNF Receptor Superfamily Member 13C
Introduction
Tnfrsf13c is a B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. It promotes the survival of mature B-cells and the B-cell response.
Entrez Gene ID
72049
UniProt ID
Q9D8D0
Alternative Names
Bcmd; Baffr; Bcmd1; BAFF-R; Bcmd-1; Lvis22; 2010006P15Rik
Function
B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.
Biological Process
Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process B cell costimulation Source:GO_Central1 Publication
Biological Process positive regulation of B cell proliferation Source:GO_Central1 Publication
Biological Process positive regulation of T cell proliferation Source:GO_Central1 Publication
Biological Process T cell costimulation Source:GO_Central1 Publication
Biological Process tumor necrosis factor-mediated signaling pathway Source:InterPro
Cellular Location
Membrane
Involvement in disease
Immunodeficiency, common variable, 4 (CVID4):
A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
Topology
Extracellular: 1-78
Helical: 79-99
Cytoplasmic: 100-184
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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