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Mouse Anti-TNFRSF13C Recombinant Antibody (CBWJC-2436) (CBMAB-C3480WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJC-2436
Antibody Isotype
IgG1, κ
Application
FC, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50 mM Sodium Phosphate, pH 7.5, 100 mM Potassium Chloride, 150mM NaCl, 0.5% Gentamicin sulfate
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TNFRSF13C Gene(Protein Coding) TNF Receptor Superfamily Member 13C
Introduction
B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]
Entrez Gene ID
115650
UniProt ID
Q96RJ3
Alternative Names
TNF Receptor Superfamily Member 13C; BLyS Receptor 3; BAFF Receptor; BAFF-R; BAFFR; Tumor Necrosis Factor Receptor Superfamily, Member 13C; Tumor Necrosis Factor Receptor Superfamily Member 13C; B Cell-Activating Factor Receptor;
Function
B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.
Biological Process
Biological Process adaptive immune response Source:UniProtKB-KW
Biological Process B cell costimulation Source:GO_Central1 Publication
Biological Process positive regulation of B cell proliferation Source:GO_Central1 Publication
Biological Process positive regulation of T cell proliferation Source:GO_Central1 Publication
Biological Process T cell costimulation Source:GO_Central1 Publication
Biological Process tumor necrosis factor-mediated signaling pathway Source:InterPro
Cellular Location
Membrane
Involvement in disease
Immunodeficiency, common variable, 4 (CVID4):
A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
Topology
Extracellular: 1-78
Helical: 79-99
Cytoplasmic: 100-184
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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