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Mouse Anti-TNFRSF10A Recombinant Antibody (32A242) (CBMAB-D2283-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
32A242
Antibody Isotype
IgG1
Application
ICC, IF, WB

Basic Information

Immunogen
Synthetic peptide corresponding to residues 2-21 of mature human DR4
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TNFRSF10A Gene(Protein Coding) TNF Receptor Superfamily Member 10a
Introduction
TNFRSF10A is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.
Entrez Gene ID
8797
UniProt ID
O00220
Alternative Names
TNF Receptor Superfamily Member 10a; Tumor Necrosis Factor Receptor Superfamily, Member 10a; TNF-Related Apoptosis-Inducing Ligand Receptor 1; Death Receptor 4; TRAIL Receptor 1; TRAIL-R1; TRAILR1; APO2;
Function
Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518).
The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (PubMed:19090789).
Promotes the activation of NF-kappa-B (PubMed:9430227).
Biological Process
Biological Process activation of NF-kappaB-inducing kinase activitySource:UniProtKB2 Publications
Biological Process apoptotic processSource:UniProtKB1 Publication
Biological Process cellular response to mechanical stimulusSource:UniProtKB1 Publication
Biological Process extrinsic apoptotic signaling pathwaySource:UniProtKB1 Publication
Biological Process extrinsic apoptotic signaling pathway via death domain receptorsSource:ProtInc1 Publication
Biological Process positive regulation of apoptotic processSource:GO_Central1 Publication
Biological Process signal transductionSource:ProtInc1 Publication
Biological Process TRAIL-activated apoptotic signaling pathwaySource:ParkinsonsUK-UCL1 Publication
Cellular Location
Cell membrane
Membrane raft
Cytoplasm, cytosol
Palmitoylation is required for association with membranes.
Topology
Extracellular: 24-239
Helical: 240-262
Cytoplasmic: 263-468
PTM
Palmitoylated (PubMed:19090789).
Palmitoylation of TNFRSF10A is required for its association with lipid rafts, oligomerization and function in TRAIL-induced cell death (PubMed:19090789).
Palmitoylated by ZDHHC3 (Probable)
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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