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Rabbit Anti-TNC Recombinant Antibody (CBYJT-3601) (CBMAB-T2933-YJ)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBYJT-3601
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TNC Gene(Protein Coding) Tenascin C
Introduction
TNC is an extracellular matrix protein with a spatially and temporally restricted tissue distribution. TNC is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. TNC is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration.
Entrez Gene ID
Human3371
Mouse21923
Rat116640
UniProt ID
HumanO15417
MouseQ80WC3
RatB2LYI9
Alternative Names
Tenascin C; Glioma-Associated-Extracellular Matrix Antigen; Deafness, Autosomal Dominant 56; Hexabrachion (Tenascin); Myotendinous Antigen; Neuronectin; GP 150-225; Cytotactin; GMEM; TN-C; HXB; TN
Function
Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327).
Biological Process
Biological Process cell adhesionSource:ProtInc1 Publication
Biological Process mesenchymal-epithelial cell signaling involved in prostate gland developmentSource:Ensembl
Biological Process neuromuscular junction developmentSource:Ensembl
Biological Process neuron projection developmentSource:GO_Central1 Publication
Biological Process osteoblast differentiationSource:UniProtKB1 Publication
Biological Process peripheral nervous system axon regenerationSource:Ensembl
Biological Process positive regulation of cell population proliferationSource:Ensembl
Biological Process positive regulation of gene expressionSource:Ensembl
Biological Process prostate gland epithelium morphogenesisSource:Ensembl
Biological Process regulation of cell adhesionSource:ComplexPortal1 Publication
Biological Process regulation of cell growthSource:ComplexPortal1 Publication
Biological Process regulation of cell migrationSource:ComplexPortal1 Publication
Biological Process regulation of inflammatory responseSource:Ensembl
Biological Process response to woundingSource:ComplexPortal1 Publication
Cellular Location
Secreted, extracellular space, extracellular matrix
Involvement in disease
Deafness, autosomal dominant, 56 (DFNA56):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA56 is characterized by progressive hearing impairment with postlingual onset.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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