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Rabbit Anti-TMPRSS2 Recombinant Antibody (CBYJT-3562) (CBMAB-T2889-YJ)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
CBYJT-3562
Antibody Isotype
IgG
Application
FC, ICC, IHC, WB

Basic Information

Immunogen
A synthetic peptide corresponding to residues in human TMPRSS2 was used as an immunogen
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, 0.05% BSA, 50% Glycerol
Preservative
0.01% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
transmembrane protease, serine 2
Introduction
TMPRSS2 is a protein that belongs to the serine protease family. TMPRSS2 contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. TMPRSS2 was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage.
Entrez Gene ID
Human7113
Mouse50528
Rat156435
Monkey715138
UniProt ID
HumanO15393
MouseQ9JIQ8
RatF1M6J6
MonkeyF6SVR2
Alternative Names
Transmembrane Protease, Serine 2; Serine Protease 10; PRSS10; Transmembrane Protease Serine 2; EC 3.4.21.109; Epitheliasin; EC 3.4.21; PP9284
Function
Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198).
Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:26018085, PubMed:25122198).
In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity).
(Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry (PubMed:24227843, PubMed:32142651, PubMed:32404436, PubMed:34159616, PubMed:33051876).
Upon SARS-CoV-2 infection, increases syncytia formation by accelerating the fusion process (PubMed:34159616, PubMed:33051876).
Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.
Biological Process
Biological Process positive regulation of viral entry into host cellSource:UniProtKB3 Publications
Biological Process protein autoprocessingSource:UniProtKB1 Publication
Biological Process proteolysisSource:UniProtKB2 Publications
Cellular Location
Cell membrane
Transmembrane protease serine
Secreted
Activated by cleavage and secreted.
Topology
Cytoplasmic: 1-84
Helical: 85-105
Extracellular: 106-492
PTM
Proteolytically processed; by an autocatalytic mechanism.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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