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Mouse Anti-TMBIM6 Recombinant Antibody (CBYJT-3455) (CBMAB-T2777-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3455
Antibody Isotype
IgM
Application
FC, ICC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS
Preservative
0.05% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Transmembrane BAX Inhibitor Motif Containing 6
Introduction
TMBIM6P (Transmembrane BAX Inhibitor Motif Containing 7, Pseudogene) is a Pseudogene.
Entrez Gene ID
7009
UniProt ID
P55061
Alternative Names
Transmembrane BAX Inhibitor Motif Containing 6; Transmembrane BAX Inhibitor Motif-Containing Protein 6; Testis-Enhanced Gene Transcript Protein; Testis Enhanced Gene Transcript; TEGT; BI-1
Function
Suppressor of apoptosis (PubMed:21075086).
Modulates unfolded protein response signaling (PubMed:21075086).
Modulates ER calcium homeostasis by acting as a calcium-leak channel (PubMed:22128171).
Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity).
Biological Process
Biological Process autophagySource:UniProtKB-KW
Biological Process cellular response to unfolded proteinSource:ParkinsonsUK-UCL1 Publication
Biological Process endoplasmic reticulum calcium ion homeostasisSource:Ensembl
Biological Process negative regulation of apoptotic processSource:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of apoptotic signaling pathwaySource:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of calcium ion transport into cytosolSource:MGI1 Publication
Biological Process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwaySource:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of endoribonuclease activitySource:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of hypoxia-induced intrinsic apoptotic signaling pathwaySource:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of immunoglobulin productionSource:Ensembl
Biological Process negative regulation of protein bindingSource:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of RNA splicingSource:ParkinsonsUK-UCL1 Publication
Biological Process negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stressSource:Ensembl
Biological Process neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressSource:Ensembl
Biological Process response to L-glutamateSource:ParkinsonsUK-UCL1 Publication
Cellular Location
Endoplasmic reticulum membrane
Topology
Cytoplasmic: 1-29
Helical: 30-50
Lumenal: 51-52
Helical: 53-73
Cytoplasmic: 74-86
Helical: 87-107
Lumenal: 108-112
Helical: 113-133
Cytoplasmic: 134-139
Helical: 140-160
Lumenal: 161-166
Helical: 167-187
Cytoplasmic: 188-206
Helical: 207-227
Cytoplasmic: 228-237
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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