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Rat Anti-Tlr7 Recombinant Antibody (CBYJT-3418) (CBMAB-T2735-YJ)


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Summary

Host Animal
Rat
Specificity
Mouse, Rat
Clone
CBYJT-3418
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
E. coli-derived recombinant mouse TLR7, Asn275-Phe444, Accession # P58681
Specificity
Mouse, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, Trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 275-444

Target

Full Name
TLR7 Gene(Protein Coding) Toll Like Receptor 7
Introduction
TLR7 is a key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. TLR7 acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Entrez Gene ID
Rat317468
Mouse170743
UniProt ID
RatA5H2Z9
MouseP58681
Alternative Names
toll-like receptor 7; Toll like receptor 7
Function
Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:14976261, PubMed:32433612).
Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs (PubMed:31608988, PubMed:27742543, PubMed:12738885, PubMed:32706371).
Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:27742543).
In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively (PubMed:27742543, PubMed:32706371).
Biological Process
Biological Process cellular response to mechanical stimulusSource:UniProtKB1 Publication
Biological Process cellular response to virusSource:Ensembl
Biological Process defense response to virusSource:UniProtKB1 Publication
Biological Process I-kappaB kinase/NF-kappaB signalingSource:GO_Central1 Publication
Biological Process I-kappaB phosphorylationSource:BHF-UCL1 Publication
Biological Process inflammatory responseSource:UniProtKB-KW
Biological Process innate immune responseSource:UniProtKB-KW
Biological Process JNK cascadeSource:Ensembl
Biological Process positive regulation of chemokine productionSource:BHF-UCL1 Publication
Biological Process positive regulation of inflammatory responseSource:BHF-UCL1 Publication
Biological Process positive regulation of interferon-alpha productionSource:UniProtKB1 Publication
Biological Process positive regulation of interferon-beta productionSource:UniProtKB1 Publication
Biological Process positive regulation of interferon-gamma productionSource:UniProtKB1 Publication
Biological Process positive regulation of interleukin-6 productionSource:GO_Central1 Publication
Biological Process positive regulation of interleukin-8 productionSource:BHF-UCL1 Publication
Biological Process positive regulation of macrophage cytokine productionSource:Ensembl
Biological Process positive regulation of NIK/NF-kappaB signalingSource:BHF-UCL1 Publication
Biological Process positive regulation of transcription by RNA polymerase IISource:Ensembl
Biological Process regulation of protein phosphorylationSource:Ensembl
Biological Process toll-like receptor 7 signaling pathwaySource:GO_Central1 Publication
Biological Process toll-like receptor signaling pathwaySource:GO_Central1 Publication
Cellular Location
Endoplasmic reticulum membrane
Endosome
Lysosome
Cytoplasmic vesicle, phagosome
Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.
Involvement in disease
Immunodeficiency 74, COVID19-related, X-linked (IMD74):
An X-linked recessive immunologic disorder characterized by impaired type I and type II interferon responses due to defective TLR7 signaling. Individuals with TLR7 deficiency develop severe respiratory insufficiency in response to infection with SARS-CoV-2 coronavirus. Death from respiratory failure may occur.
Topology
Extracellular: 27-839
Helical: 840-860
Cytoplasmic: 861-1049
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For research use only. Not intended for any clinical use.

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