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Mouse Anti-THOP1 Recombinant Antibody (CBYJT-3011) (CBMAB-T2261-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-3011
Antibody Isotype
IgG2b
Application
ICC, WB

Basic Information

Immunogen
A synthetic peptide corresponding to residues 56-72 of human thimet oligopeptidase
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
Tris-glycine, 150 mM NaCl
Preservative
0.05% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 56-72

Target

Full Name
THOP1 Gene(Protein Coding) Thimet Oligopeptidase 1
Introduction
THOP1 is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. THOP1 also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides.
Entrez Gene ID
7064
UniProt ID
P52888
Alternative Names
Thimet Oligopeptidase 1; Endopeptidase 24.15; EC 3.4.24.15; MP78; Thimet Oligopeptidase; MEPD_HUMAN; EC 3.4.24; EP24.15; TOP
Function
Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation (PubMed:7639763, PubMed:17251185).
Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (PubMed:7639763, PubMed:17251185).
Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity).
Biological Process
Biological Process peptide metabolic processSource:GO_Central1 Publication
Biological Process protein polyubiquitinationSource:Reactome
Biological Process proteolysisSource:GO_Central1 Publication
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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