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Mouse Anti-THEMIS2 Recombinant Antibody (CBLC270-LY) (CBMAB-C12496-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLC270-LY
Antibody Isotype
IgG1, κ
Application
ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
THEMIS2 Gene(Protein Coding)


Thymocyte Selection Associated Family Member 2
Introduction
THEMIS2 (Thymocyte Selection Associated Family Member 2) is a Protein Coding gene. Diseases associated with THEMIS2 include Endometrial Adenocarcinoma. An important paralog of this gene is THEMIS.
Entrez Gene ID
9473
UniProt ID
Q5TEJ8
Alternative Names
Thymocyte Selection Associated Family Member 2; Thymocyte-Expressed Molecule Involved In Selection Protein 2; Induced By Contact To Basement Membrane 1 Protein; Protein ICB-1; C1orf38; Induced By Contact To Basement Membrane 1;
Function
May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production (PubMed:20644716).
Determines the threshold for activation of B cells by low-affinity and low-avidity ligands via PLCG2 activation and its downstream pathways (By similarity).
Biological Process
Biological Process cell adhesionSource:ProtInc1 Publication
Biological Process inflammatory responseSource:UniProtKB-KW
Biological Process regulation of B cell activationSource:UniProtKB
Biological Process T cell receptor signaling pathwaySource:GO_Central1 Publication
Cellular Location
Nucleus
Cytoplasm
PTM
Phosphorylation at Tyr-632 is induced by LPS. Phosphorylated by Src kinases (Lck or Fyn) following BCR engagement.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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