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Mouse Anti-TEAD3 Recombinant Antibody (CBYJT-2481) (CBMAB-T1630-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-2481
Antibody Isotype
IgG2b, κ
Application
ELISA, IF

Basic Information

Immunogen
Partial recombinant corresponding to aa215-303 from human TEAD3 (NP_003205) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 215-303

Target

Full Name
TEAD3
Introduction
TEAD3 is a transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. TEAD3 acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. It binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.
Entrez Gene ID
7005
UniProt ID
Q99594
Alternative Names
TEF5; TEAD5; TEF-5; DTEF-1; ETFR-1; TEAD-3
Function
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.
Biological Process
Biological Process asymmetric neuroblast divisionIGI:UniProtKB1 Publication
Biological Process embryonic organ developmentIBA:GO_Central1 Publication
Biological Process female pregnancyTAS:ProtInc1 Publication
Biological Process hippo signalingIDA:UniProtKB2 Publications
Biological Process positive regulation of transcription by RNA polymerase IIIEA:InterPro
Biological Process regulation of transcription by RNA polymerase IIIBA:GO_Central1 Publication
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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