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Mouse Anti-Tau Recombinant Antibody (HT7) (CBMAB-0479CQ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Cattle
Clone
HT7
Antibody Isotype
IgG1, κ
Application
WB, IF, ICC, IHC-P, ELISA

Basic Information

Immunogen
Purified human Tau, epitope human Tau between residue 159 and 163 (numbering according to human Tau40), from the amino acid sequence PPGQK.
Specificity
Human, Mouse, Rat, Cattle
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Tau
Introduction
The microtubule-associated proteins (MAPs) coassemble with tubulin into microtubules in vitro. Microtubule-associated protein tau appears to be enriched in axons. This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. Andreadis et al. (1992) found that the tau isoforms that predominate in human brain are encoded by 11 exons. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Entrez Gene ID
Human4137
Mouse17762
Rat29477
Cattle281296
UniProt ID
HumanP10636
MouseP10637
RatP19332
CattleP29172
Alternative Names
TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103
More Infomation

Nadel, C. M., Thwin, A. C., Callahan, M., Lee, K., Connelly, E., Craik, C. S., ... & Gestwicki, J. E. (2023). The E3 Ubiquitin Ligase, CHIP/STUB1, Inhibits Aggregation of Phosphorylated Proteoforms of Microtubule-associated Protein Tau (MAPT). Journal of Molecular Biology, 435(11), 168026.

Brandt, R., Trushina, N. I., & Bakota, L. (2020). Much more than a cytoskeletal protein: physiological and pathological functions of the non-microtubule binding region of tau. Frontiers in Neurology, 11, 590059.

Han, X., Sekino, Y., Babasaki, T., Goto, K., Inoue, S., Hayashi, T., ... & Matsubara, A. (2020, June). Microtubule-associated protein tau (MAPT) is a promising independent prognostic marker and tumor suppressive protein in clear cell renal cell carcinoma. In Urologic Oncology: Seminars and Original Investigations (Vol. 38, No. 6, pp. 605-e9). Elsevier.

Sekino, Y., Han, X., Babasaki, T., Goto, K., Inoue, S., Hayashi, T., ... & Matsubara, A. (2020, October). Microtubule-associated protein tau (MAPT) promotes bicalutamide resistance and is associated with survival in prostate cancer. In Urologic Oncology: Seminars and Original Investigations (Vol. 38, No. 10, pp. 795-e1). Elsevier.

Schroeder, C., Grell, J., Hube-Magg, C., Kluth, M., Lang, D., Simon, R., ... & Steurer, S. (2019). Aberrant expression of the microtubule-associated protein tau is an independent prognostic feature in prostate cancer. BMC cancer, 19, 1-10.

Barbier, P., Zejneli, O., Martinho, M., Lasorsa, A., Belle, V., Smet-Nocca, C., ... & Landrieu, I. (2019). Role of tau as a microtubule-associated protein: structural and functional aspects. Frontiers in aging neuroscience, 11, 204.

Xu, Y., Zhang, S., & Zheng, H. (2019). The cargo receptor SQSTM1 ameliorates neurofibrillary tangle pathology and spreading through selective targeting of pathological MAPT (microtubule associated protein tau). Autophagy, 15(4), 583-598.

Olczak, M., Poniatowski, Ł. A., Niderla-Bielińska, J., Kwiatkowska, M., Chutorański, D., Tarka, S., & Wierzba-Bobrowicz, T. (2019). Concentration of microtubule associated protein tau (mapt) in urine and saliva as a potential biomarker of traumatic brain injury in relationship with blood–brain barrier disruption in postmortem examination. Forensic science international, 301, 28-36.

Melková, K., Zapletal, V., Narasimhan, S., Jansen, S., Hritz, J., Škrabana, R., ... & Žídek, L. (2019). Structure and functions of microtubule associated proteins tau and MAP2c: similarities and differences. Biomolecules, 9(3), 105.

Gaig, C., Ercilla, G., Daura, X., Ezquerra, M., Fernández-Santiago, R., Palou, E., ... & Graus, F. (2019). HLA and microtubule-associated protein tau H1 haplotype associations in anti-IgLON5 disease. Neurology-Neuroimmunology Neuroinflammation, 6(6).

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For research use only. Not intended for any clinical use.

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