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Mouse Anti-TAGLN Recombinant Antibody (CBYJT-1909) (CBMAB-T0989-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1909
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa1-202 from human TAGLN (AAH04927) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-202

Target

Full Name
TAGLN Gene(Protein Coding) Transgelin
Introduction
TAGLN is a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. TAGLN is thought to be involved in calcium-independent smooth muscle contraction. TAGLN acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. TAGLN has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization.
Entrez Gene ID
6876
UniProt ID
Q01995
Alternative Names
Transgelin; SM22-Alpha; Smooth Muscle Protein 22-Alpha; 22 KDa Actin-Binding Protein; Transgelin Variant 2; WS3-10
Function
Actin cross-linking/gelling protein (By similarity).
Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.
Biological Process
Biological Process epithelial cell differentiationIDA:UniProtKB1 Publication
Biological Process muscle organ developmentTAS:ProtInc1 Publication
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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