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Mouse Anti-TAGLN Recombinant Antibody (3A3) (CBMAB-A8856-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3A3
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
TAGLN (AAH04927, 1 a.a. ~ 201 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
TAGLN Gene(Protein Coding) Transgelin
Introduction
The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq]
Entrez Gene ID
6876
UniProt ID
Q01995
Alternative Names
DKFZp686P11128; SM22; SMCC; TAGLN1; WS3-10
Function
Actin cross-linking/gelling protein (By similarity).
Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.
Biological Process
Biological Process epithelial cell differentiationIDA:UniProtKB1 Publication
Biological Process muscle organ developmentTAS:ProtInc1 Publication
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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