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Mouse Anti-SYNPO Recombinant Antibody (G1D4) (CBMAB-S6338-CQ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Pig, Rat, Gerbil, Guinea pig, Cattle
Clone
G1D4
Antibody Isotype
IgG1
Application
WB, IHC-P, IHC-Fr

Basic Information

Immunogen
Isolated Rat Kidney Glomeruli
Specificity
Human, Mouse, Pig, Rat, Gerbil, Guinea pig, Cattle
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Synaptopodin
Introduction
Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. The name synaptopodin derives from the protein's associations with postsynaptic densities and dendritic spines and with renal podocytes (Mundel et al., 1997 [PubMed 9314539]).
Entrez Gene ID
Human11346
Mouse104027
Rat60324
Pig110259543
Guinea pig100728174
Cattle533531
UniProt ID
HumanQ8N3V7
MouseQ8CC35
RatQ9Z327
PigA0A286ZLL9
Guinea pigA0A286XX54
CattleE1BA93
Alternative Names
Synaptopodin
Function
Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity (By similarity).
Biological Process
Biological Process modification of dendritic spineIDA:SynGO1 Publication
Biological Process positive regulation of actin filament bundle assemblyISS:UniProtKB1 Publication
Biological Process regulation of stress fiber assemblyISS:UniProtKB
Biological Process spine apparatus assemblyIBA:GO_Central1 Publication
Cellular Location
Cytoplasm, cytoskeleton
Cell junction, tight junction
Perikaryon
Cell projection, dendritic spine
Postsynaptic density
Synapse
Cytoplasm, cytosol
Localized at the tight junction of cells. In brain, localized to the postsynaptic densities and in the perikarya. Associated with dendritic spines of a subset of synapses.
PTM
O-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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