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Mouse Anti-STEAP4 Recombinant Antibody (CBXS-1823) (CBMAB-S0123-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-1823
Antibody Isotype
IgG2b
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.2 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
STEAP4 Metalloreductase
Introduction
The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
79689
UniProt ID
Q687X5
Alternative Names
STAMP2; SchLAH; TIARP; TNFAIP9
Function
Integral membrane protein that functions as NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe3+ chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe3+ chelate (PubMed:30337524).
Can also reduce Cu2+ to Cu1+ (By similarity).
Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity).
Associated with obesity and insulin-resistance (PubMed:18430367, PubMed:18381574).
Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107).
Inhibits anchorage-independent cell proliferation (PubMed:19787193).
Biological Process
Biological Process copper ion importManual Assertion Based On ExperimentIBA:GO_Central
Biological Process fat cell differentiationISS:UniProtKB
Biological Process iron import into cellIEA:Ensembl
Biological Process protein homotrimerizationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cell membrane
Golgi apparatus membrane
Early endosome membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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