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Rabbit Anti-SSTR2 Monoclonal Antibody (UMB1) (CBMAB-1499-YC)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
UMB1
Antibody Isotype
IgG
Application
IHC-Fr, IHC-P, IP, WB

Basic Information

Immunogen
Synthetic peptide corresponding to Human Somatostatin Receptor 2 aa 350-450 (C terminal).
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Somatostatin Receptor 2
Introduction
SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney.
Entrez Gene ID
Human6752
Mouse20606
Rat54305
UniProt ID
HumanP30874
MouseP30875
RatP30680
Alternative Names
somatostatin receptor type 2; SRIF-1; SS2R
Function
Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.
Biological Process
Biological Process adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayIEA:Ensembl
Biological Process cellular response to estradiol stimulusManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to glucocorticoid stimulusManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cerebellum developmentIEA:Ensembl
Biological Process forebrain developmentIEA:Ensembl
Biological Process G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process peristalsisIEA:Ensembl
Biological Process regulation of muscle contractionIEA:Ensembl
Biological Process response to starvationIEA:Ensembl
Biological Process spermatogenesisIEA:Ensembl
Cellular Location
Cell membrane ; Multi-pass membrane protein
Cytoplasm
Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm.
Topology
Extracellular: 1-43
Helical: 44-67
Cytoplasmic: 68-78
Helical: 79-103
Extracellular: 104-118
Helical: 119-138
Cytoplasmic: 139-161
Helical: 162-181
Extracellular: 182-207
Helical: 208-229
Cytoplasmic: 230-253
Helical: 254-278
Extracellular: 279-288
Helical: 289-303
Cytoplasmic: 304-369
PTM
Phosphorylated on serine and threonine residues in response to agonist stimulation, leading to receptor desensitization and rapid internalization. Phosphorylated to a greater extent on serine than threonine residues. Threonine phosphorylation is required for arrestin binding and receptor endocytosis but is not necessary for desensitization (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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