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Mouse Anti-SPTAN1 Recombinant Antibody (3D7) (CBMAB-1824-CN)


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Summary

Host Animal
Mouse
Specificity
Human, Rat, Cattle
Clone
3D7
Antibody Isotype
IgG1
Application
WB, IF

Basic Information

Immunogen
Recombinant fragment containing the seventh, eighth and ninth repeats of Human Alpha Fodrin expressed in and purified from E. Coli
Specificity
Human, Rat, Cattle
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
99% PBS
Preservative
0.07% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Spectrin alpha chain, non-erythrocytic 1
Introduction
This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
Entrez Gene ID
Human6709
Cattle540108
Rat64159
UniProt ID
HumanQ13813
CattleE1BFB0
RatP16086
Alternative Names
NEAS; EIEE5; SPTA2
Function
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
Biological Process
Biological Process actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process actin filament cappingIEA:UniProtKB-KW
Cellular Location
Cytoplasm, cytoskeleton
Cytoplasm, cell cortex
Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells.
Involvement in disease
Developmental and epileptic encephalopathy 5 (DEE5):
A disorder characterized by seizures associated with hypsarrhythmia, profound intellectual disability with lack of visual attention and speech development, as well as spastic quadriplegia.
PTM
Phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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