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Rabbit Anti-SPON2 Recombinant Antibody (CBXS-1647) (CBMAB-S4496-CQ)


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Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBXS-1647
Antibody Isotype
IgG
Application
WB, FC

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Spondin 2
Introduction
SPON2 (Spondin 2) is a Protein Coding gene. Among its related pathways are Integrin Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include antigen binding and lipopolysaccharide binding. An important paralog of this gene is SPON1.
Entrez Gene ID
Human10417
Mouse100689
Rat171569
UniProt ID
HumanQ9BUD6
MouseQ8BMS2
RatQ9WV75
Alternative Names
Spondin 2; Mindin; Differentially Expressed In Cancerous And Non-Cancerous Lung Cells 1; Spondin 2, Extracellular Matrix Protein; M-Spondin; DIL-1; DIL1; Spondin-2;
Function
Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity).
Binds bacterial lipopolysaccharide (LPS).
Biological Process
Biological Process cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to lipopolysaccharideIEA:Ensembl
Biological Process defense response to fungusIEA:Ensembl
Biological Process defense response to virusIEA:Ensembl
Biological Process induction of bacterial agglutinationIEA:Ensembl
Biological Process innate immune responseIEA:UniProtKB-KW
Biological Process mast cell mediated immunityIEA:Ensembl
Biological Process opsonizationIEA:Ensembl
Biological Process positive regulation of interleukin-6 productionIEA:Ensembl
Biological Process positive regulation of macrophage cytokine productionIEA:Ensembl
Biological Process positive regulation of tumor necrosis factor productionIEA:Ensembl
Cellular Location
Secreted, extracellular space, extracellular matrix
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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