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Rabbit Anti-SPATA18 Recombinant Antibody (CBXS-1364) (CBMAB-S4222-CQ)


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Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBXS-1364
Antibody Isotype
IgG
Application
WB, IHC-P, IF

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1.872 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Spermatogenesis Associated 18
Introduction
This gene encodes a p53-inducible protein that is able to induce lysosome-like organelles within mitochondria that eliminate oxidized mitochondrial proteins, thereby contributing to mitochondrial quality control. Dysregulation of mitochondrial quality control is associated with cancer and degenerative diseases. The encoded protein mediates accumulation of the lysosome-like mitochondrial organelles through interaction with B cell lymphoma 2 interacting protein 3 and B cell lymphoma 2 interacting protein 3 like at the outer mitochondrial membrane, which allows translocation of lysosomal proteins to the mitochondrial matrix from the cytosol. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
Human132671
Mouse73472
Rat289586
UniProt ID
HumanQ8TC71
MouseQ0P557
RatQ6AYL6
Alternative Names
Spermatogenesis Associated 18; Mieap; Spermatogenesis Associated 18 Homolog (Rat); Testis Tissue Sperm-Binding Protein Li 71n; Spermatogenesis Associated 18 Homolog; Spermatogenesis-Associated Protein 18; Mitochondria-Eating Protein; SPETEX1;
Function
Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix.
Biological Process
Biological Process cellular response to DNA damage stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process mitochondrial protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitophagy by induced vacuole formationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Mitochondrion outer membrane
Localizes to the cytoplasm under normal conditions (PubMed:21264228).
Relocalizes to mitochondrion outer membrane following cellular stress. Colocalizes with BNIP3 and BNIP3L at the mitochondrion outer membrane (PubMed:22292033).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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