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Rabbit Anti-SPARC Recombinant Antibody (CBXS-5327) (CBMAB-S2541-CQ)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
CBXS-5327
Antibody Isotype
IgG
Application
WB, IHC-P

Basic Information

Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SPARC
Introduction
This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
Human6678
Mouse20692
UniProt ID
HumanP09486
MouseP07214
Alternative Names
Secreted Protein Acidic And Cysteine Rich; Secreted Protein Acidic And Rich In Cysteine; Basement-Membrane Protein 40; Osteonectin; BM-40; ON; Secreted Protein, Acidic, Cysteine-Rich (Osteonectin); Cysteine-Rich Protein; OI17;
Function
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca2+ with a low affinity and an EF-hand loop that binds a Ca2+ ion with a high affinity.
Biological Process
Biological Process anatomical structure developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of angiogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of endothelial cell proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of endothelial cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of cell morphogenesisManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Secreted, extracellular space, extracellular matrix, basement membrane
In or around the basement membrane.
Involvement in disease
Osteogenesis imperfecta 17 (OI17):
An autosomal recessive form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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