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Mouse Anti-SP110 Recombinant Antibody (CBXS-5927) (CBMAB-S0776-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-5927
Antibody Isotype
IgG2a, κ
Application
ELISA, IP, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SP110
Introduction
The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified.
Entrez Gene ID
3431
UniProt ID
Q9HB58
Alternative Names
SP110 Nuclear Body Protein; Interferon-Induced Protein 41, 30kD; Transcriptional Coactivator Sp110; Interferon-Induced Protein 41/75; Speckled 110 KDa; Interferon-Induced Protein 75, 52kD; Phosphoprotein 41;
Function
Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE).
Biological Process
Regulation of transcription by RNA polymerase II
Cellular Location
Nucleus
Found in the nuclear body.
Involvement in disease
Hepatic venoocclusive disease with immunodeficiency (VODI):
Autosomal recessive primary immunodeficiency associated with hepatic vascular occlusion and fibrosis. The immunodeficiency is characterized by severe hypogammaglobulinemia, combined T and B-cell immunodeficiency, absent lymph node germinal centers, and absent tissue plasma cells.
PTM
Phosphorylated (isoform 2).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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