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Mouse Anti-SOCS2 Recombinant Antibody (CBXS-1845) (CBMAB-S4648-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-1845
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Recombinant human SOCS-2, Met1-Gln197 (predicted), Accession # O14508
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SOCS2
Introduction
This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants.
Entrez Gene ID
8835
UniProt ID
O14508
Alternative Names
Suppressor Of Cytokine Signaling 2; Cytokine-Inducible SH2 Protein 2; STAT-Induced STAT Inhibitor 2; SOCS-2; STATI2; CIS-2;
Function
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Biological Process
Biological Process cellular response to hormone stimulusManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process growth hormone receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process intracellular signal transductionIEA:Ensembl
Biological Process lactationIEA:Ensembl
Biological Process mammary gland alveolus developmentIEA:Ensembl
Biological Process negative regulation of apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process negative regulation of multicellular organism growthIEA:Ensembl
Biological Process negative regulation of receptor signaling pathway via JAK-STATIEA:Ensembl
Biological Process phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of neuron differentiationIEA:Ensembl
Biological Process protein ubiquitinationIEA:UniProtKB-UniPathway
Biological Process receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentTAS:ProtInc
Biological Process regulation of cell growth1 PublicationNAS:UniProtKB
Biological Process regulation of signal transduction1 PublicationNAS:UniProtKB
Biological Process response to estradiolManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
cytoplasm
cytosol
phosphatidylinositol 3-kinase complex
PTM
Ubiquitinated; mediated by AREL1 and leading to its subsequent proteasomal degradation (PubMed:31578312).
Ubiquitination is dependent on its phosphorylation at Ser-52, by PKC (PubMed:31578312).
Ubiquitination is stimulated by LPS (By similarity).
Phosphorylation at Ser-52 by PKC facilitates its ubiquitination and proteosomal degradation.
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For research use only. Not intended for any clinical use.

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