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Mouse Anti-SNUPN Recombinant Antibody (2B2-1B4) (CBMAB-A7689-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2B2-1B4
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
RNUT1 (AAH04203, 1 a.a. ~ 360 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Snurportin 1
Introduction
The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq]
Entrez Gene ID
10073
UniProt ID
O95149
Alternative Names
KPNBL; RNUT1; Snurportin1
Function
Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.
Biological Process
Biological Process protein import into nucleusIEA:InterPro
Biological Process RNA import into nucleusManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process snRNA import into nucleusIEA:InterPro
Cellular Location
Nucleus
Cytoplasm
Nucleoplasmic shuttling protein. Its nuclear import involves the nucleocytoplasmic transport receptor importin beta (PubMed:10209022, PubMed:12095920).
It is re-exported to the cytoplasm by the XPO1-dependent nuclear export receptor pathway (PubMed:10209022).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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