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Mouse Anti-SNRPA (AA 1-283) Recombinant Antibody (CBXS-0616) (CBMAB-S3558-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0616
Antibody Isotype
IgG1
Application
ELISA, ICC, IHC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.09% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-283

Target

Full Name
Small Nuclear Ribonucleoprotein Polypeptide A
Introduction
The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation.
Entrez Gene ID
6626
UniProt ID
P09012
Alternative Names
Small Nuclear Ribonucleoprotein Polypeptide A; U1 SnRNP A; U1-A; U1A; U1 Small Nuclear Ribonucleoprotein A; U1 Small Nuclear RNP-Specific A; U1 SnRNP-Specific Protein A; Mud1;
Function
Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs.
Biological Process
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of mRNA polyadenylationIEA:Ensembl
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

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