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Mouse Anti-SNCG Recombinant Antibody (CBLNG-182) (CBMAB-1823-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLNG-182
Antibody Isotype
IgG1
Application
WB, ICC, IHC

Basic Information

Immunogen
E. coli-derived recombinant human gamma-Synuclein
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Synuclein Gamma
Introduction
This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. The protein plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. Diseases associated with SNCG include Breast Cancer and Synucleinopathy. GO annotations related to this gene include beta-tubulin binding and alpha-tubulin binding.
Entrez Gene ID
6623
UniProt ID
O76070
Alternative Names
SR; BCSG1
Function
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity).
May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).
Biological Process
Biological Process adult locomotory behaviorIEA:Ensembl
Biological Process chemical synaptic transmissionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein secretionIEA:Ensembl
Biological Process regulation of dopamine secretionIEA:Ensembl
Biological Process regulation of neuron deathManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of neurotransmitter secretionIEA:Ensembl
Biological Process synapse organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process synaptic vesicle endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm, perinuclear region
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Cytoplasm, cytoskeleton, spindle
Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle.
PTM
Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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