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Rabbit Anti-SMYD2 Recombinant Antibody (CBXS-0584) (CBMAB-S3526-CQ)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey, Hamster, Cattle, Dog, Horse
Clone
CBXS-0584
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Mouse, Rat, Monkey, Hamster, Cattle, Dog, Horse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SET And MYND Domain Containing 2
Introduction
SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 [PubMed 16805913]).
Entrez Gene ID
Human56950
Mouse226830
Rat289372
Monkey709375
Hamster100761694
Horse100052774
Dog480026
Cattle615229
UniProt ID
HumanQ9NRG4
MouseQ8R5A0
RatQ7M6Z3
MonkeyF6RU02
HamsterA0A3Q0DBP0
HorseF6Z0W8
DogA0A8I3ME68
CattleQ0P585
Alternative Names
SET And MYND Domain Containing 2; SET And MYND Domain-Containing Protein 2; Histone Methyltransferase SMYD2; Lysine N-Methyltransferase 3C; HSKM-B; KMT3C;
Function
Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.
Biological Process
Biological Process chromatin organizationIEA:UniProtKB-KW
Biological Process heart developmentIEA:Ensembl
Biological Process histone lysine methylationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of cell population proliferationISS:UniProtKB
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process peptidyl-lysine dimethylationISS:UniProtKB
Biological Process peptidyl-lysine monomethylationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of DNA damage response, signal transduction by p53 class mediatorManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of signal transduction by p53 class mediatorTAS:Reactome
Cellular Location
Cytoplasm, cytosol
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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