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Mouse Anti-SMURF1 Monoclonal Antibody (1A10) (CBMAB-0143-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1A10
Antibody Isotype
IgG2b
Application
IP, ELISA

Basic Information

Immunogen
Recombinant peptide (Full Length)
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
SMURF1
Introduction
This gene encodes a ubiquitin ligase that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein (BMP) pathway. This protein plays a key roll in the regulation of cell motility, cell signalling, and cell polarity. Alternative splicing results in multiple transcript variants encoding different isoforms. E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS.
Entrez Gene ID
57154
UniProt ID
Q9HCE7
Alternative Names
KIAA1625
Function
E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404).
Plays a role in dendrite formation by melanocytes (PubMed:23999003).
Biological Process
Biological Process BMP signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process ectoderm developmentManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process engulfment of target by autophagosomeManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process negative regulation of BMP signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process negative regulation of transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of axon extensionIEA:Ensembl
Biological Process positive regulation of dendrite extensionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:CACAO
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process protein export from nucleusManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process protein localization to cell surfaceManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process protein localization to plasma membraneManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Biological Process protein polyubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein targeting to vacuole involved in autophagyManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process protein ubiquitinationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process receptor catabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process substrate localization to autophagosomeManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Biological Process ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process ubiquitin-dependent SMAD protein catabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process Wnt signaling pathway, planar cell polarity pathwayTAS:Reactome
Cellular Location
Cytoplasm
Cell membrane
PTM
Auto-ubiquitinated in presence of NDFIP1 (PubMed:23087404).
Ubiquitinated by the SCF(FBXL15) complex at Lys-381 and Lys-383, leading to its degradation by the proteasome. Lys-383 is the primary ubiquitination site.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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