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Mouse Anti-SMPD2 Recombinant Antibody (CBXS-4465) (CBMAB-S1707-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4465
Antibody Isotype
IgG3, κ
Application
ELISA, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG3, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Concentration
0.25 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
Introduction
This gene encodes a protein which was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase.
Entrez Gene ID
6610
UniProt ID
O60906
Alternative Names
Sphingomyelin Phosphodiesterase 2; Neutral Sphingomyelinase; Lyso-Platelet-Activating Factor-Phospholipase C; Lyso-PAF-PLC; N-SMase; NSMASE;
Function
Catalyzes, at least in vitro, the hydrolysis of sphingomyelin to form ceramide and phosphocholine (PubMed:10608884).
Also hydrolyzes 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor) in vivo (PubMed:10608884).
Also acts on 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and sphingosylphosphocholine (PubMed:10608884, PubMed:14741383).
Biological Process
Biological Process ceramide biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sphingolipid catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sphingomyelin catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process sphingomyelin metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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